Intracellular screening of a peptide library to derive a potent peptide inhibitor of α-synuclein aggregation
H Cheruvara, VL Allen-Baume, NM Kad… - Journal of Biological …, 2015 - ASBMB
Background: Deposition of α-synuclein into Lewy bodies is considered the primary event in
Parkinson disease. Results: A peptide selected via PCA library screening functions by
inhibiting fibril formation. Conclusion: A semirational design combined with intracellular PCA
Parkinson disease. Results: A peptide selected via PCA library screening functions by
inhibiting fibril formation. Conclusion: A semirational design combined with intracellular PCA
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