N-terminal additions to the WE14 peptide of chromogranin A create strong autoantigen agonists in type 1 diabetes
N Jin, Y Wang, F Crawford, J White… - Proceedings of the …, 2015 - National Acad Sciences
Abstract Chromogranin A (ChgA) is an autoantigen for CD4+ T cells in the nonobese
diabetic (NOD) mouse model of type 1 diabetes (T1D). The natural ChgA-processed
peptide, WE14, is a weak agonist for the prototypical T cell, BDC-2.5, and other ChgA …
diabetic (NOD) mouse model of type 1 diabetes (T1D). The natural ChgA-processed
peptide, WE14, is a weak agonist for the prototypical T cell, BDC-2.5, and other ChgA …
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