STING activator c-di-GMP enhances the anti-tumor effects of peptide vaccines in melanoma-bearing mice

STING activator c-di-GMP enhances the anti-tumor effects of peptide vaccines in melanoma-bearing mice

Z Wang, E Celis - Cancer Immunology, Immunotherapy, 2015 - Springer

Abstract Therapeutic vaccines to induce anti-tumor CD8 T cells have been used in clinical
trials for advanced melanoma patients, but the clinical response rate and overall survival
time have not improved much. We believe that these dismal outcomes are caused by

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