The positively charged COOH-terminal glycosaminoglycan-binding CXCL9 (74–103) peptide inhibits CXCL8-induced neutrophil extravasation and monosodium urate …

The positively charged COOH-terminal glycosaminoglycan-binding CXCL9 (74–103) peptide inhibits CXCL8-induced neutrophil extravasation and monosodium urate …

V Vanheule, R Janssens, D Boff, N Kitic… - Journal of Biological …, 2015 - ASBMB

Results: CXCL9 (74–103), derived from CXCL9, lacks leukocyte-attracting activity but
competes with CXCL8 for GAG binding and inhibits neutrophil migration in two murine acute
inflammation models. Conclusion: Through inhibition of chemokine-GAG interaction, CXCL9

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