2017年12月18日星期一

Peptide–MHC-based nanomedicines for autoimmunity function as T-cell receptor microclustering devices

Peptide–MHC-based nanomedicines for autoimmunity function as T-cell receptor microclustering devices

S SinghaK Shao, Y Yang, X Clemente-Casares… - Nature …, 2017 - nature.com
We have shown that nanoparticles (NPs) can be used as ligand-multimerization platforms to
activate specific cellular receptors in vivo. Nanoparticles coated with autoimmune disease-
relevant peptide-major histocompatibility complexes (pMHC) blunted autoimmune 


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