2018年2月6日星期二

Discovery of the once-weekly glucagon-like peptide-1 (GLP-1) analogue semaglutide

Discovery of the once-weekly glucagon-like peptide-1 (GLP-1) analogue semaglutide

J Lau, P Bloch, L Schäffer, I Pettersson… - Journal of medicinal …, 2015 - ACS Publications
Liraglutide is an acylated glucagon-like peptide-1 (GLP-1) analogue that binds to serum
albumin in vivo and is approved for once-daily treatment of diabetes as well as obesity. The
aim of the present studies was to design a once weekly GLP-1 analogue by increasing


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