gp100/pmel 17 is a murine tumor rejection antigen: induction of “self”-reactive, tumoricidal T cells using high-affinity, altered peptide ligand
WW Overwijk, A Tsung, KR Irvine… - Journal of …, 1998 - jem.rupress.org
Many tumor-associated antigens are nonmutated, poorly immunogenic tissue differentiation
antigens. Their weak immunogenicity may be due to “self”-tolerance. To induce autoreactive
T cells, we studied immune responses to gp100/pmel 17, an antigen naturally expressed by
antigens. Their weak immunogenicity may be due to “self”-tolerance. To induce autoreactive
T cells, we studied immune responses to gp100/pmel 17, an antigen naturally expressed by
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