Basophils contribute to TH 2-IgE responses in vivo via IL-4 production and presentation of peptide–MHC class II complexes to CD4+ T cells
T Yoshimoto, K Yasuda, H Tanaka, M Nakahira… - Nature …, 2009 - nature.com
Abstract Basophils express major histocompatibility complex class II, CD80 and CD86 and
produce interleukin 4 (IL-4) in various conditions. Here we show that when incubated with IL-
3 and antigen or complexes of antigen and immunoglobulin E (IgE), basophils internalized,
produce interleukin 4 (IL-4) in various conditions. Here we show that when incubated with IL-
3 and antigen or complexes of antigen and immunoglobulin E (IgE), basophils internalized,
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