2018年2月3日星期六

Presence of soluble amyloid β–peptide precedes amyloid plaque formation in Down's syndrome

Presence of soluble amyloid β–peptide precedes amyloid plaque formation in Down's syndrome

JK Teller, C Russo, LM Debusk, G Angelini, D Zaccheo… - Nature medicine, 1996 - Springer
Abstract Abnormal and excessive accumulation of the amyloid β–peptide (Aβ) in the brain is
a major and common characteristic of all Alzheimer's disease (AD) forms irrespective of their
genetic background. Insoluble aggregates of Aβ are identified as amyloid plaques. These


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