Sequence-specific, nanomolar peptide binding via cucurbit [8] uril-induced folding and inclusion of neighboring side chains

Sequence-specific, nanomolar peptide binding via cucurbit [8] uril-induced folding and inclusion of neighboring side chains

LC Smith, DG Leach, BE Blaylock, OA Ali… - Journal of the …, 2015 - ACS Publications

This paper describes the molecular recognition of the tripeptide Tyr-Leu-Ala by the synthetic
receptor cucurbit [8] uril (Q8) in aqueous buffer with nanomolar affinity and exceptional
specificity. This combination of characteristics, which also applies to antibodies, is desirable

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