Ligand binding pocket formed by evolutionarily conserved residues in the glucagon-like peptide-1 (GLP-1) receptor core domain

Ligand binding pocket formed by evolutionarily conserved residues in the glucagon-like peptide-1 (GLP-1) receptor core domain

MJ Moon, YN Lee, S Park, A Reyes-Alcaraz… - Journal of Biological …, 2015 - ASBMB

Background: Little is known about the interaction between GLP-1 and the heptahelical core
domain of GLP1R. Results: GLP-1 Asp 9 and Gly 4 interact with the evolutionarily conserved
residues in extracellular loop 3. Conclusion: Ligand binding pocket formed by evolutionarily

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