The immune modulatory peptide FhHDM-1 secreted by the helminth Fasciola hepatica prevents NLRP3 inflammasome activation by inhibiting endolysosomal …
R Alvarado, J To, ME Lund, A Pinar, A Mansell… - The FASEB Journal, 2017 - FASEB
Abstract The NLRP3 inflammasome is a multimeric protein complex that controls the
production of IL-1β, a cytokine that influences the development of both innate and adaptive
immune responses. Helminth parasites secrete molecules that interact with innate immune
production of IL-1β, a cytokine that influences the development of both innate and adaptive
immune responses. Helminth parasites secrete molecules that interact with innate immune
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