PEGylation of the peptide Bac7 (1–35) reduces renal clearance while retaining antibacterial activity and bacterial cell penetration capacity

PEGylation of the peptide Bac7 (1–35) reduces renal clearance while retaining antibacterial activity and bacterial cell penetration capacity

M Benincasa, S Zahariev, C Pelillo, A Milan… - European journal of …, 2015 - Elsevier

Abstract The proline-rich antibacterial peptide Bac7 (1–35) protects mice against Salmonella
typhimurium infection, despite its rapid clearance. To overcome this problem the peptide 
was linked to a polyethylene glycol (PEG) molecule either via a cleavable ester bond or via …

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