2018年6月28日星期四

The pivotal role of high glucose-induced overexpression of PKCβ in the appearance of glucagon-like peptide-1 resistance in endothelial cells

The pivotal role of high glucose-induced overexpression of PKCβ in the appearance of glucagon-like peptide-1 resistance in endothelial cells

G Pujadas, V De Nigris, L La Sala, R Testa… - Endocrine, 2016 - Springer
Recently, it has been demonstrated that Glucagon-like peptide-1 (GLP-1) has a protective
effect on endothelial cells. Our hypothesis is that this GLP-1 protective effect is partly lost
when the cells are exposed to sustained high glucose concentrations. Human umbilical vein …


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