Modified nanoparticles with cell-penetrating peptide and amphipathic chitosan derivative for enhanced oral colon absorption of insulin: preparation and evaluation
F Guo, M Zhang, Y Gao, S Zhu, S Chen, W Liu… - Drug …, 2016 - Taylor & Francis
Colon is an ideal absorptive site for oral protein and peptide drug (insulin), and yet it poses
multiple barriers against the drug absorption, such as the barriers against the drug diffusion
from colon lumen toward the absorptive mucosa and permeation across colon epithelium. In …
multiple barriers against the drug absorption, such as the barriers against the drug diffusion
from colon lumen toward the absorptive mucosa and permeation across colon epithelium. In …
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