Dominant role of the ERAP1 polymorphism R528K in shaping the HLA–B27 peptidome through differential processing determined by multiple peptide residues

Dominant role of the ERAP1 polymorphism R528K in shaping the HLA–B27 peptidome through differential processing determined by multiple peptide residues

A Sanz‐Bravo, J Campos… - Arthritis & …, 2015 - Wiley Online Library

Objective To characterize the alterations, as well as their mechanisms, induced in the HLA–
B27–bound peptidome expressed in live cells by the natural ERAP1 polymorphisms
predisposing to ankylosing spondylitis (AS): R528K and N575D/Q725R. Methods HLA–B …

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