Uncleaved ApoM signal peptide is required for formation of large ApoM/sphingosine 1-phosphate (S1P)-enriched HDL particles

Uncleaved ApoM signal peptide is required for formation of large ApoM/sphingosine 1-phosphate (S1P)-enriched HDL particles

M Liu, J Allegood, X Zhu, J Seo, AK Gebre… - Journal of Biological …, 2015 - ASBMB

Results: ApoM Q22A overexpression generates smaller nascent and plasma HDL and
enhances apoM and S1P secretion as compared with apoM WT. Conclusion: ApoM
secretion regulates hepatocyte S1P secretion, and its uncleaved signal peptide delays …

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