A hydrogen-bonded polar network in the core of the glucagon-like peptide-1 receptor is a fulcrum for biased agonism: lessons from class B crystal structures.
DM Wootten, CA Reynolds, C Koole, KJ Smith… - Molecular …, 2015 - ASPET
The glucagon-like peptide 1 (GLP-1) receptor is a class BG protein-coupled receptor
(GPCR) that is a key target for treatments for type II diabetes and obesity. This receptor, like
other class B GPCRs, displays biased agonism, though the physiological significance of this …
(GPCR) that is a key target for treatments for type II diabetes and obesity. This receptor, like
other class B GPCRs, displays biased agonism, though the physiological significance of this …
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